A Novel in Vivo Model for the Study of Hiv-1

6 7 Miguel Stevens 1 , Michela Pollicita 5 , Christophe Pannecouque 1 , Erik Verbeken 2 , Oriana 8 Tabarrini 3 , Violetta Cecchetti 3 , Stefano Aquaro 4 , Carlo Federico Perno 5 , 9 Arnaldo Fravolini 3 , Erik De Clercq 1 , Dominique Schols 1 and Jan Balzarini 1* 10 11 12 1 Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, 13 Belgium 14 2 Division of Histopathology, University Hospitals, Katholieke Universiteit Leuven, B-3000 15 Leuven, Belgium 16 3 Department of Chemistry and Technology of Drug, University of Perugia, Via del Liceo, 17 06123 Perugia, Italy 18 4 Department of Pharmaco-Biology, University of Calabria, 87030 Rende (CS), Italy 19 5 Department of Experimental Medicine and Biochemical Sciences, University of Rome 20 ‘Tor Vergata’, Via Montpellier 1, 00133 Rome, Italy 21 22 23 * To whom correspondence and reprint requests should be adressed at the Rega Institute for 24 Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium. Fax 32-16-337340. E25 mail: [email protected] 26 27 Running head: Quinolones inhibit HIV-1 transcription in vivo 28 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.01251-06 AAC Accepts, published online ahead of print on 22 January 2007